Chemistry and Pharmacological Studies of 3-Alkoxy-2,5-Disubstituted-Pyridinyl Compounds as Novel Selective α4β2 Nicotinic Acetylcholine Receptor Ligands That Reduces Alcohol Intake in Rats

Neuronal acetylcholine receptors mediate the addictive effects of nicotine and may also be involved in alcohol addiction. Varenicline, an approved smoking cessation medication, showed clear efficacy in reducing alcohol consumption in heavy-drinking smokers. More recently, sazetidine-A, which selecti...

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Autori principali: Liu, Yong, Richardson, Janell, Tran, Thao, Al-Muhtasib, Nour, Xie, Teresa, Yenugonda, Venkata Mahidhar, Sexton, Hannah G., Rezvani, Amir H., Levin, Edward D., Sahibzada, Niaz, Kellar, Kenneth J., Brown, Milton L., Xiao, Yingxian, Paige, Mikell
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809750/
https://ncbi.nlm.nih.gov/pubmed/23540678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4000374
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