AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors

AT-1001 [N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1] nonan-3-amine] is a high-affinity and highly selective ligand at α3β4 nicotinic cholinergic receptors (nAChRs) that was reported to decrease nicotine self-administration in rats. It was initially reported to be an antagonist at rat α3β4 nAChRs...

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Udgivet i:Mol Pharmacol
Main Authors: Tuan, Edward W., Horti, Andrew G., Olson, Thao T., Gao, Yongiun, Stockmeier, Craig A., Al-Muhtasib, Nour, Bowman Dalley, Carrie, Lewin, Amanda E., Wolfe, Barry B., Sahibzada, Niaz, Xiao, Yingxian, Kellar, Kenneth J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576681/
https://ncbi.nlm.nih.gov/pubmed/26162864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099978
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