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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.

The covalent joining of topoisomerases to DNA is normally a transient step in the reaction cycle of these important enzymes. However, under a variety of circumstances, the covalent complex is converted to a long-lived or dead-end product that can result in chromosome breakage and cell death. We have...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yang, S W, Burgin, A B, Huizenga, B N, Robertson, C A, Yao, K C, Nash, H A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38092/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8876170/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.21.11534
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