C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels

Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest. Kv11.1 channels are members of the KCNH subfamily of...

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Bibliographic Details
Main Authors: Ng, Chai Ann, Ke, Ying, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Vandenberg, Jamie I.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808384/
https://ncbi.nlm.nih.gov/pubmed/24204727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077032
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