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Transcriptional Suppression of CYP2A13 Expression by Lipopolysaccharide in Cultured Human Lung Cells and the Lungs of a CYP2A13-Humanized Mouse Model

CYP2A13, a human P450 enzyme preferentially expressed in the respiratory tract, is highly efficient in the metabolic activation of tobacco-specific nitrosamines. The aim of this study was to test the hypothesis that inflammation suppresses CYP2A13 expression in the lung, thus explaining the large in...

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Detalles Bibliográficos
Main Authors: Wu, Hong, Liu, Zhihua, Ling, Guoyu, Lawrence, David, Ding, Xinxin
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807623/
https://ncbi.nlm.nih.gov/pubmed/23884085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft165
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