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Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers
CYP2A13, a human cytochrome P450 enzyme expressed mainly in the respiratory tract, is believed to play an important role in the initiation of smoking-induced lung cancer. CYP2A13.1 has a high efficiency in the metabolic activation of a major tobacco-specific carcinogenic nitrosamine, 4-(methylnitros...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597635/ https://ncbi.nlm.nih.gov/pubmed/18669584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022822 |
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