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Mechanisms of Differential Expression of the CYP2A13 7520C and 7520G Alleles in Human Lung: Allelic Expression Analysis for CYP2A13 Heterogeneous Nuclear RNA, and Evidence for the Involvement of Multiple Cis-Regulatory Single Nucleotide Polymorphisms
OBJECTIVE: To identify the mechanisms underlying the decreased allelic expression of a common CYP2A13 allele (7520C>G) in the human lung; CYP2A13 is expressed selectively in the respiratory tract, and is highly efficient in the metabolic activation of several chemical carcinogens. METHODS: The 75...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2875259/ https://ncbi.nlm.nih.gov/pubmed/20431511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283313aa5 |
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