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Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers

CYP2A13, a human cytochrome P450 enzyme expressed mainly in the respiratory tract, is believed to play an important role in the initiation of smoking-induced lung cancer. CYP2A13.1 has a high efficiency in the metabolic activation of a major tobacco-specific carcinogenic nitrosamine, 4-(methylnitros...

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Bibliografske podrobnosti
Main Authors: D’Agostino, Jaime, Zhang, Xiuling, Wu, Hong, Ling, Guoyu, Wang, Suping, Zhang, Qing-Yu, Liu, Fucai, Ding, Xinxin
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597635/
https://ncbi.nlm.nih.gov/pubmed/18669584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.022822
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