Inhibition of RelA-Ser536 Phosphorylation by a Competing Peptide Reduces Mouse Liver Fibrosis Without Blocking the Innate Immune Response

Phosphorylation of the RelA subunit at serine 536 (RelA-P-Ser536) is important for hepatic myofibroblast survival and is mechanistically implicated in liver fibrosis. Here, we show that a cell-permeable competing peptide (P6) functions as a specific targeted inhibitor of RelA-P-Ser536 in vivo and ex...

詳細記述

保存先:
書誌詳細
主要な著者: Moles, Anna, Sanchez, Ana M, Banks, Paul S, Murphy, Lindsay B, Luli, Saimir, Borthwick, Lee, Fisher, Andrew, O’Reilly, Steven, van Laar, Jacob M, White, Steven A, Perkins, Neil D, Burt, Alastair D, Mann, Derek A, Oakley, Fiona
フォーマット: Artigo
言語:Inglês
出版事項: Wiley Subscription Services, Inc., A Wiley Company 2013
主題:
Liver Injury/Regeneration
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807604/
https://ncbi.nlm.nih.gov/pubmed/22996371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26068
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