Inhibition of RelA-Ser536 Phosphorylation by a Competing Peptide Reduces Mouse Liver Fibrosis Without Blocking the Innate Immune Response

Phosphorylation of the RelA subunit at serine 536 (RelA-P-Ser536) is important for hepatic myofibroblast survival and is mechanistically implicated in liver fibrosis. Here, we show that a cell-permeable competing peptide (P6) functions as a specific targeted inhibitor of RelA-P-Ser536 in vivo and ex...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Moles, Anna, Sanchez, Ana M, Banks, Paul S, Murphy, Lindsay B, Luli, Saimir, Borthwick, Lee, Fisher, Andrew, O’Reilly, Steven, van Laar, Jacob M, White, Steven A, Perkins, Neil D, Burt, Alastair D, Mann, Derek A, Oakley, Fiona
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2013
Assuntos:
Liver Injury/Regeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807604/
https://ncbi.nlm.nih.gov/pubmed/22996371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26068
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados