Inhibition of RelA-Ser536 Phosphorylation by a Competing Peptide Reduces Mouse Liver Fibrosis Without Blocking the Innate Immune Response

Phosphorylation of the RelA subunit at serine 536 (RelA-P-Ser536) is important for hepatic myofibroblast survival and is mechanistically implicated in liver fibrosis. Here, we show that a cell-permeable competing peptide (P6) functions as a specific targeted inhibitor of RelA-P-Ser536 in vivo and ex...

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Detalles Bibliográficos
Autores principales: Moles, Anna, Sanchez, Ana M, Banks, Paul S, Murphy, Lindsay B, Luli, Saimir, Borthwick, Lee, Fisher, Andrew, O’Reilly, Steven, van Laar, Jacob M, White, Steven A, Perkins, Neil D, Burt, Alastair D, Mann, Derek A, Oakley, Fiona
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2013
Materias:
Liver Injury/Regeneration
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807604/
https://ncbi.nlm.nih.gov/pubmed/22996371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26068
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