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Mitochondrial Nucleases ENDOG and EXOG Participate in Mitochondrial DNA Depletion Initiated by Herpes Simplex Virus 1 UL12.5
Herpes simplex virus 1 (HSV-1) rapidly eliminates mitochondrial DNA (mtDNA) from infected cells, an effect that is mediated by UL12.5, a mitochondrial isoform of the viral alkaline nuclease UL12. Our initial hypothesis was that UL12.5 directly degrades mtDNA via its nuclease activity. However, we sh...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807374/ https://ncbi.nlm.nih.gov/pubmed/23986585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02306-13 |
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