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Quantifying Selection against Synonymous Mutations in HIV-1 env Evolution
Intrapatient evolution of human immunodeficiency virus type 1 (HIV-1) is driven by the adaptive immune system resulting in rapid change of HIV-1 proteins. When cytotoxic CD8(+) T cells or neutralizing antibodies target a new epitope, the virus often escapes via nonsynonymous mutations that impair re...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3807363/ https://ncbi.nlm.nih.gov/pubmed/23986591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01529-13 |
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