Evolution of the HIV-1 env Gene in the Rag2(−/−) γ(C)(−/−) Humanized Mouse Model

Rag2(−/−) γ(C)(−/−) mice transplanted with human hematopoietic stem cells (DKO-hu-HSC mice) mimic aspects of human infection with human immunodeficiency virus type 1 (HIV-1), including sustained viral replication and CD4(+) T-cell decline. However, the extent of HIV-1 evolution during long-term infe...

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Detalhes bibliográficos
Main Authors: Ince, William L., Zhang, Liguo, Jiang, Qi, Arrildt, Kathryn, Su, Lishan, Swanstrom, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2826074/
https://ncbi.nlm.nih.gov/pubmed/20042504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02180-09
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