Suppression of Human Immunodeficiency Virus Type 1 (HIV-1) Viremia with Reverse Transcriptase and Integrase Inhibitors, CD4(+) T-Cell Recovery, and Viral Rebound upon Interruption of Therapy in a New Model for HIV Treatment in the Humanized Rag2(−/−)γ(c)(−/−) Mouse

A small animal model that reproduces human immunodeficiency virus type 1 (HIV-1) pathogenesis may allow modeling of new therapeutic strategies in ways not approachable in mononuclear cell culture. We find that, as in humans, combination antiretroviral therapy (ART) in humanized (hu-) Rag2(−/−)γ(c)(−...

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Detalhes bibliográficos
Main Authors: Choudhary, Shailesh K., Rezk, Naser L., Ince, William L., Cheema, Manzoor, Zhang, Liguo, Su, Lishan, Swanstrom, Ronald, Kashuba, Angela D. M., Margolis, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715775/
https://ncbi.nlm.nih.gov/pubmed/19494021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00580-09
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