mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription

We report a function of human mRNA decapping factors in control of transcription by RNA polymerase II. Decapping proteins Edc3, Dcp1a and Dcp2 and the termination factor, TTF2, co-immunoprecipitate with Xrn2, the nuclear 5′-3′ exonuclease “torpedo” that facilitates transcription termination at the 3...

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Autores principales: Brannan, Kris, Kim, Hyunmin, Erickson, Benjamin, Glover-Cutter, Kira, Kim, Soojin, Fong, Nova, Kiemele, Lauren, Hansen, Kirk, Davis, Richard, Lykke-Andersen, Jens, Bentley, David L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806456/
https://ncbi.nlm.nih.gov/pubmed/22483619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.006
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