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mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription
We report a function of human mRNA decapping factors in control of transcription by RNA polymerase II. Decapping proteins Edc3, Dcp1a and Dcp2 and the termination factor, TTF2, co-immunoprecipitate with Xrn2, the nuclear 5′-3′ exonuclease “torpedo” that facilitates transcription termination at the 3...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806456/ https://ncbi.nlm.nih.gov/pubmed/22483619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.006 |
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