Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors

The TWEAK (TNFSF12) receptor Fn14 (TNFRSF12A) is expressed at low levels in normal tissues but frequently highly expressed in a wide range of tumor types such as lung, melanoma, and breast and therefore it is a potentially unique therapeutic target for these diverse tumor types. We have generated a...

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Bibliographic Details
Main Authors: Zhou, Hong, Hittelman, Walter N., Yagita, Hideo, Cheung, Lawrence H., Martin, Stuart S., Winkles, Jeffrey A., Rosenblum, Michael G.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805367/
https://ncbi.nlm.nih.gov/pubmed/23722548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0187
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