Development of Human Serine Protease-based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC

The cytokine TWEAK and its receptor, Fn14, have emerged as potentially valuable targets for cancer therapy. Granzyme B (GrB)-containing Fn14-targeted constructs were generated containing either the Fn14 ligand TWEAK (GrB-TWEAK) or an anti-Fn14 humanized single-chain antibody (GrB-Fc-IT4) as the targ...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Ther
Huvudupphovsmän: Zhou, Hong, Mohamedali, Khalid A., Gonzalez-Angulo, Ana Maria, Cao, Yu, Migliorini, Mary, Cheung, Lawrence H., LoBello, Janine, Lei, Xiudong, Qi, Yuan, Hittelman, Walter N., Winkles, Jeffrey A., Tran, Nhan L., Rosenblum, Michael G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276724/
https://ncbi.nlm.nih.gov/pubmed/25239934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0346
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