The TWEAK Receptor Fn14 is a Novel Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment

Fn14, the cell surface receptor for TWEAK, is over-expressed in various human solid tumor types and can be a negative prognostic indicator. We detected Fn14 expression in ~60% of the melanoma cell lines we tested, including both B-Raf WT and B-Raf(V600E) lines. Tumor tissue microarray analysis indic...

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Hauptverfasser: Zhou, Hong, Ekmekcioglu, Suhendan, Marks, John W., Mohamedali, Khalid A., Asrani, Kaushal, Phillips, Keeley K., Brown, Sharron A.N., Cheng, Emily, Weiss, Michele B., Hittelman, Walter N., Tran, Nhan L., Yagita, Hideo, Winkles, Jeffrey A., Rosenblum, Michael G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600159/
https://ncbi.nlm.nih.gov/pubmed/23190886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.402
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