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Cyclopropenimine-Catalyzed Enantioselective Mannich Reactions of t-Butyl Glycinates with N-Boc-Imines

Cyclopropenimine 1 is shown to catalyze Mannich reactions between glycine imines and N-Boc-aldimines with high levels of enantio- and diastereocontrol. The reactivity of 1 is shown to be substantially greater than a widely used thiourea cinchona alkaloid derived catalyst. A variety of aryl and aliph...

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Detalhes bibliográficos
Main Authors: Bandar, Jeffrey S., Lambert, Tristan H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804837/
https://ncbi.nlm.nih.gov/pubmed/23906087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja407277a
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