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The Mannich Reaction of Malonates with Simple Imines Catalyzed by Bifunctional Cinchona Alkaloids: Enantioselective Synthesis of β-Amino Acids
[Image: see text] We describe the first efficient, direct asymmetric Mannich reactions with malonates and N-Boc aryl and alkyl imines by cooperative hydrogen bonding catalysis with a cinchona alkaloid bearing a thiourea functionality. We have also extended the scope of this reaction to β-ketoesters....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172002/ https://ncbi.nlm.nih.gov/pubmed/16669669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja060716f |
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