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Molybdopterin biosynthesis: Trapping an unusual purine ribose adduct in the MoaA-catalyzed reaction

MoaA/MoaC catalyze a remarkable rearrangement reaction in which guanosine-5′-triphosphate (GTP) is converted to cyclicpyranopterin monophosphate (cPMP). In this reaction, the C8 of GTP is inserted between the C2′ and the C3′ carbons of the GTP ribose. Previous experiments with GTP isotopomers demons...

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Detalhes bibliográficos
Main Authors: Mehta, Angad P., Abdelwahed, Sameh H., Begley, Tadhg P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804160/
https://ncbi.nlm.nih.gov/pubmed/23848839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4041048
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