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Catalysis of a new ribose carbon–insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA

MoaA, a radical S-adenosylmethionine (SAM) enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphtate is inserted between the C2′ and the C3′ carbons of the ribose. This study identifies the site of initial hy...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mehta, Angad P., Hanes, Jeremiah W., Abdelwahed, Sameh H., Hilmey, David G., Hänzelmann, Petra, Begley, Tadhg P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582411/
https://ncbi.nlm.nih.gov/pubmed/23286307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3016026
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