Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T-cells

PURPOSE: The adoptive transfer of T-cells modified to express a chimeric antigen receptor (CAR) comprised of an extracellular single chain antibody (scFV) fragment specific for a tumor cell surface molecule, and linked to an intracellular signaling module has activity in advanced malignancies. ROR1...

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Hlavní autoři: Hudecek, Michael, Lupo-Stanghellini, Maria-Teresa, Kosasih, Paula L., Sommermeyer, Daniel, Jensen, Michael C., Rader, Christoph, Riddell, Stanley R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804130/
https://ncbi.nlm.nih.gov/pubmed/23620405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0330
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