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The non-signaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity

The use of synthetic chimeric antigen receptors (CAR) to redirect T cells to recognize tumor provides a powerful new approach to cancer immunotherapy; however the attributes of CARs that ensure optimal in vivo tumor recognition remain to be defined. Here, we analyze the influence of length and compo...

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Podrobná bibliografie
Vydáno v:Cancer Immunol Res
Hlavní autoři: Hudecek, Michael, Sommermeyer, Daniel, Kosasih, Paula L., Silva-Benedict, Anne, Liu, Lingfeng, Rader, Christoph, Jensen, Michael C., Riddell, Stanley R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692801/
https://ncbi.nlm.nih.gov/pubmed/25212991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0127
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