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The non-signaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity

The use of synthetic chimeric antigen receptors (CAR) to redirect T cells to recognize tumor provides a powerful new approach to cancer immunotherapy; however the attributes of CARs that ensure optimal in vivo tumor recognition remain to be defined. Here, we analyze the influence of length and compo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Immunol Res
Prif Awduron: Hudecek, Michael, Sommermeyer, Daniel, Kosasih, Paula L., Silva-Benedict, Anne, Liu, Lingfeng, Rader, Christoph, Jensen, Michael C., Riddell, Stanley R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692801/
https://ncbi.nlm.nih.gov/pubmed/25212991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0127
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