The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor

Monoclonal antibodies and T cells modified to express chimeric antigen receptors specific for B-cell lineage surface molecules such as CD20 exert antitumor activity in B-cell malignancies, but deplete normal B cells. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) was identified as a high...

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Autors principals: Hudecek, Michael, Schmitt, Thomas M., Baskar, Sivasubramanian, Lupo-Stanghellini, Maria Teresa, Nishida, Tetsuya, Yamamoto, Tori N., Bleakley, Marie, Turtle, Cameron J., Chang, Wen-Chung, Greisman, Harvey A., Wood, Brent, Maloney, David G., Jensen, Michael C., Rader, Christoph, Riddell, Stanley R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996114/
https://ncbi.nlm.nih.gov/pubmed/20702778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-05-283309
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