IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

A single high dose of interferon-β (IFNβ) activates powerful cellular responses, in which many anti-viral, pro-apoptotic, and anti-proliferative proteins are highly expressed. Since some of these proteins are deleterious, cells downregulate this initial response rapidly. However, the expression of m...

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Main Authors: Cheon, HyeonJoo, Holvey-Bates, Elise G, Schoggins, John W, Forster, Samuel, Hertzog, Paul, Imanaka, Naoko, Rice, Charles M, Jackson, Mark W, Junk, Damian J, Stark, George R
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801437/
https://ncbi.nlm.nih.gov/pubmed/24065129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.203
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