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Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death
High expression of 2′,5′‐oligoadenylate synthetase 1 (OAS1), which adds AMP residues in 2′,5′ linkage to a variety of substrates, is observed in many cancers as a part of the interferon‐related DNA damage resistance signature (IRDS). Poly(ADP‐ribose) (PAR) is rapidly synthesized from NAD (+) at site...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7265237/ https://ncbi.nlm.nih.gov/pubmed/32323871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101573 |
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