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A Secondary Gate As a Mechanism for Inhibition of the M2 Proton Channel by Amantadine

The mechanism of inhibition of the influenza A virus M2 proton channel by the antiviral drug amantadine has been under intense investigation. The importance of a mechanistic understanding is heightened by the prevalence of amantadine-resistant mutations. To gain mechanistic insight at the molecular...

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Bibliografiske detaljer
Main Authors: Yi, Myunggi, Cross, Timothy A., Zhou, Huan-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801206/
https://ncbi.nlm.nih.gov/pubmed/18476738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp800171m
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