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A Secondary Gate As a Mechanism for Inhibition of the M2 Proton Channel by Amantadine
The mechanism of inhibition of the influenza A virus M2 proton channel by the antiviral drug amantadine has been under intense investigation. The importance of a mechanistic understanding is heightened by the prevalence of amantadine-resistant mutations. To gain mechanistic insight at the molecular...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801206/ https://ncbi.nlm.nih.gov/pubmed/18476738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp800171m |
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