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Solid-State NMR and MD Simulations of the Antiviral Drug Amantadine Solubilized in DMPC Bilayers

The interactions of (15)N-labeled amantadine, an antiinfluenza A drug, with DMPC bilayers were investigated by solid-state NMR and by a 12.6-ns molecular dynamics (MD) simulation. The drug was found to assume a single preferred orientation and location when incorporated in these bilayers. The experi...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Conggang, Yi, Myunggi, Hu, Jun, Zhou, Huan-Xiang, Cross, Timothy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2008
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212701/
https://ncbi.nlm.nih.gov/pubmed/17890391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.112482
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