p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

Macrophages are a major target cell for HIV-1, and their infection contributes to HIV pathogenesis. We have previously shown that the cyclin-dependent kinase inhibitor p21 inhibits the replication of HIV-1 and other primate lentiviruses in human monocyte-derived macrophages by impairing reverse tran...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Allouch, Awatef, David, Annie, Amie, Sarah M., Lahouassa, Hichem, Chartier, Loïc, Margottin-Goguet, Florence, Barré-Sinoussi, Françoise, Kim, Baek, Sáez-Cirión, Asier, Pancino, Gianfranco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2013
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801060/
https://ncbi.nlm.nih.gov/pubmed/24082141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306719110
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