p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity

HIV-1 infection of noncycling cells, such as dendritic cells (DCs), is impaired due to limited availability of deoxynucleoside triphosphates (dNTPs), which are needed for HIV-1 reverse transcription. The levels of dNTPs are tightly regulated during the cell cycle and depend on the balance between dN...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Valle-Casuso, Jose Carlos, Allouch, Awatef, David, Annie, Lenzi, Gina M., Studdard, Lydia, Barré-Sinoussi, Françoise, Müller-Trutwin, Michaela, Kim, Baek, Pancino, Gianfranco, Sáez-Cirión, Asier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686764/
https://ncbi.nlm.nih.gov/pubmed/28931685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01324-17
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