Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity

DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of phosphohistone 2AX (γH2AX) upon UV irradiation-induced replication stress. Surprisingly, the strongest reduction of phosphohistone 2AX followed knockd...

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Detalhes bibliográficos
Main Authors: Köpper, Frederik, Bierwirth, Cathrin, Schön, Margarete, Kunze, Meike, Elvers, Ingegerd, Kranz, Dominique, Saini, Priyanka, Menon, Manoj B., Walter, David, Sørensen, Claus Storgaard, Gaestel, Matthias, Helleday, Thomas, Schön, Michael P., Dobbelstein, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801042/
https://ncbi.nlm.nih.gov/pubmed/24082115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304355110
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