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Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

Cisplatin is widely used against various tumors, but resistance is commonly encountered. By inducing DNA crosslinks, cisplatin triggers DNA damage response (DDR) and cell death. However, the molecular determinants of how cells respond to cisplatin are incompletely understood. Since ubiquitination pl...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Schmidt, Franziska, Kunze, Meike, Loock, Ann-Christine, Dobbelstein, Matthias
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359243/
https://ncbi.nlm.nih.gov/pubmed/25593194
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