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Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

Cisplatin is widely used against various tumors, but resistance is commonly encountered. By inducing DNA crosslinks, cisplatin triggers DNA damage response (DDR) and cell death. However, the molecular determinants of how cells respond to cisplatin are incompletely understood. Since ubiquitination pl...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Schmidt, Franziska, Kunze, Meike, Loock, Ann-Christine, Dobbelstein, Matthias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359243/
https://ncbi.nlm.nih.gov/pubmed/25593194
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