Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Uterine leiomyomas are extremely common estrogen and progesterone-dependent tumors of the myometrium and cause irregular uterine bleeding, severe anemia, and recurrent pregnancy loss in 15–30% of reproductive-age women. Each leiomyoma is thought to arise from a single mutated myometrial smooth muscl...

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Detalhes bibliográficos
Main Authors: Ono, Masanori, Yin, Ping, Navarro, Antonia, Moravek, Molly B., Coon, John S., Druschitz, Stacy A., Serna, Vanida Ann, Qiang, Wenan, Brooks, David C., Malpani, Saurabh S., Ma, Jiajia, Ercan, Cihangir Mutlu, Mittal, Navdha, Monsivais, Diana, Dyson, Matthew T., Yemelyanov, Alex, Maruyama, Tetsuo, Chakravarti, Debabrata, Kim, J. Julie, Kurita, Takeshi, Gottardi, Cara J., Bulun, Serdar E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801037/
https://ncbi.nlm.nih.gov/pubmed/24082114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313650110
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