Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Uterine leiomyomas are extremely common estrogen and progesterone-dependent tumors of the myometrium and cause irregular uterine bleeding, severe anemia, and recurrent pregnancy loss in 15–30% of reproductive-age women. Each leiomyoma is thought to arise from a single mutated myometrial smooth muscl...

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Autors principals: Ono, Masanori, Yin, Ping, Navarro, Antonia, Moravek, Molly B., Coon, John S., Druschitz, Stacy A., Serna, Vanida Ann, Qiang, Wenan, Brooks, David C., Malpani, Saurabh S., Ma, Jiajia, Ercan, Cihangir Mutlu, Mittal, Navdha, Monsivais, Diana, Dyson, Matthew T., Yemelyanov, Alex, Maruyama, Tetsuo, Chakravarti, Debabrata, Kim, J. Julie, Kurita, Takeshi, Gottardi, Cara J., Bulun, Serdar E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801037/
https://ncbi.nlm.nih.gov/pubmed/24082114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313650110
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