MK-2206, an AKT Inhibitor, Promotes Caspase-Independent Cell Death and Inhibits Leiomyoma Growth

Uterine leiomyomas (ULs), benign tumors of the myometrium, are the number one indication for hysterectomies in the United States due to a lack of an effective alternative therapy. ULs show activation of the pro-survival AKT pathway compared with normal myometrium; however, substantial data directly...

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Detalhes bibliográficos
Main Authors: Sefton, Elizabeth C., Qiang, Wenan, Serna, Vanida, Kurita, Takeshi, Wei, Jian-Jun, Chakravarti, Debabrata, Kim, J. Julie
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Cancer-Oncogenes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800769/
https://ncbi.nlm.nih.gov/pubmed/24002033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-1389
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