Heme impairs the ball-and-chain inactivation of potassium channels

Fine-tuned regulation of K(+) channel inactivation enables excitable cells to adjust action potential firing. Fast inactivation present in some K(+) channels is mediated by the distal N-terminal structure (ball) occluding the ion permeation pathway. Here we show that Kv1.4 K(+) channels are potently...

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Autori principali: Sahoo, Nirakar, Goradia, Nishit, Ohlenschläger, Oliver, Schönherr, Roland, Friedrich, Manfred, Plass, Winfried, Kappl, Reinhard, Hoshi, Toshinori, Heinemann, Stefan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801010/
https://ncbi.nlm.nih.gov/pubmed/24082096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313247110
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