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Impact of intracellular hemin on N-type inactivation of voltage-gated K(+) channels

N-type inactivation of voltage-gated K(+) channels is conferred by the N-terminal “ball” domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, we show that hemin impairs inactivation of K(+) channels formed by Kv3.4 α subunits as...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Coburger, Ina, Yang, Kefan, Bernert, Alisa, Wiesel, Eric, Sahoo, Nirakar, Swain, Sandip M., Hoshi, Toshinori, Schönherr, Roland, Heinemann, Stefan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7239824/
https://ncbi.nlm.nih.gov/pubmed/32388729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-020-02386-1
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