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Heme impairs the ball-and-chain inactivation of potassium channels
Fine-tuned regulation of K(+) channel inactivation enables excitable cells to adjust action potential firing. Fast inactivation present in some K(+) channels is mediated by the distal N-terminal structure (ball) occluding the ion permeation pathway. Here we show that Kv1.4 K(+) channels are potently...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801010/ https://ncbi.nlm.nih.gov/pubmed/24082096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313247110 |
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