Discovery and Computer Aided Potency Optimization of a Novel Class of Small Molecule CXCR4 Antagonists

Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process. High CXCR4 tumour expression is associated with poor prognosis of lung, b...

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Main Authors: Vinader, Victoria, Ahmet, Djevdet S., Ahmed, Mohaned S., Patterson, Laurence H., Afarinkia, Kamyar
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800133/
https://ncbi.nlm.nih.gov/pubmed/24205302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078744
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