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Discovery and Computer Aided Potency Optimization of a Novel Class of Small Molecule CXCR4 Antagonists
Amongst the chemokine signalling axes involved in cancer, chemokine CXCL12 acting on chemokine receptor CXCR4 is particularly significant since it orchestrates migration of cancer cells in a tissue-specific metastatic process. High CXCR4 tumour expression is associated with poor prognosis of lung, b...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3800133/ https://ncbi.nlm.nih.gov/pubmed/24205302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078744 |
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