Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression

Both genes and the environment are determinants in the susceptibility to allergies and may alter the severity of the disease. We explored whether an increase in the levels of the lipid mediator S1P in vivo, a condition found during allergic asthma, could affect the sensitivity or the response of MCs...

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Autors principals: Olivera, Ana, Kitamura, Yoshiaki, Wright, Laurel D., Allende, Maria L., Chen, Weiping, Kaneko-Goto, Tomomi, Yoshihara, Yoshihiro, Proia, Richard L., Rivera, Juan
Format: Artigo
Idioma:Inglês
Publicat: Society for Leukocyte Biology 2013
Matèries:
Receptors, Signal Transduction, & Genes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800067/
https://ncbi.nlm.nih.gov/pubmed/23904439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313163
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