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Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression

Both genes and the environment are determinants in the susceptibility to allergies and may alter the severity of the disease. We explored whether an increase in the levels of the lipid mediator S1P in vivo, a condition found during allergic asthma, could affect the sensitivity or the response of MCs...

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Main Authors: Olivera, Ana, Kitamura, Yoshiaki, Wright, Laurel D., Allende, Maria L., Chen, Weiping, Kaneko-Goto, Tomomi, Yoshihara, Yoshihiro, Proia, Richard L., Rivera, Juan
Formato: Artigo
Idioma:Inglês
Publicado: Society for Leukocyte Biology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800067/
https://ncbi.nlm.nih.gov/pubmed/23904439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0313163
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