Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

Sphingosine kinase 1 (SphK1) and SphK2 are ubiquitous enzymes that generate sphingosine-1-phosphate (S1P), a ligand for a family of G protein–coupled receptors (S1PR1–S1PR5) with important functions in the vascular and immune systems. Here we explore the role of these kinases and receptors in recove...

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Detalhes bibliográficos
Main Authors: Olivera, Ana, Eisner, Christoph, Kitamura, Yoshiaki, Dillahunt, Sandra, Allende, Laura, Tuymetova, Galina, Watford, Wendy, Meylan, Francoise, Diesner, Susanne C., Li, Lingli, Schnermann, Jurgen, Proia, Richard L., Rivera, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860904/
https://ncbi.nlm.nih.gov/pubmed/20407207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40659
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