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CBX8, a component of the repressive Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3
AF9 is known to interact with multiple proteins including activators and repressors of transcription. Our data indicate that other AF9 binding proteins compete with the histone methyltransferase DOT1L for AF9 binding thus diminishing its ability to methylate lysine 79 of histone 3. Specifically, we...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3800029/ https://ncbi.nlm.nih.gov/pubmed/23891621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.07.034 |
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