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The VHL tumor suppressor and HIF: insights from genetic studies in mice
The von Hippel–Lindau tumor suppressor gene product, pVHL, functions as the substrate recognition component of an E3-ubiquitin ligase, which targets the oxygen-sensitive α-subunit of hypoxia-inducible factor (HIF) for rapid proteasomal degradation under normoxic conditions and as such plays a centra...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799983/ https://ncbi.nlm.nih.gov/pubmed/18219317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.cdd.4402313 |
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