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The VHL tumor suppressor in development and disease: Functional studies in mice by conditional gene targeting
The von Hippel–Lindau tumor suppressor pVHL plays a critical role in the pathogenesis of familial and sporadic clear cell carcinomas of the kidney and hemangioblastomas of the retina and central nervous system. pVHL targets the oxygen sensitive alpha subunit of hypoxia-inducible factor (HIF) for pro...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787877/ https://ncbi.nlm.nih.gov/pubmed/15908240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2005.03.006 |
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