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Human Papillomavirus Type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase complex that orchestrates mitotic progression by targeting key mitotic regulators for proteasomal degradation. APC/C dysfunction is a frequent event during cancer development and can give rise to genomic instability. Here we repo...

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Detalhes bibliográficos
Main Authors: Yu, Yueyang, Munger, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799973/
https://ncbi.nlm.nih.gov/pubmed/24074588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.08.013
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