Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA)

BACKGROUND: Epigenetic programming, dynamically regulated by histone acetylation, is a key mechanism regulating cell proliferation and survival. Little is known about the contribution of histone deacetylase (HDAC) activity to the development of pulmonary arterial hypertension (PAH), a condition char...

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Main Authors: Zhao, Lan, Chen, Chien-Nien, Hajji, Nabil, Oliver, Eduardo, Cotroneo, Emanuele, Wharton, John, Wang, Daren, Li, Min, McKinsey, Timothy A., Stenmark, Kurt R., Wilkins, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799888/
https://ncbi.nlm.nih.gov/pubmed/22711276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.103176
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