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Accounting for epistatic interactions improves the functional analysis of protein structures
Motivation: The constraints under which sequence, structure and function coevolve are not fully understood. Bringing this mutual relationship to light can reveal the molecular basis of binding, catalysis and allostery, thereby identifying function and rationally guiding protein redesign. Underlying...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799481/ https://ncbi.nlm.nih.gov/pubmed/24021383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btt489 |
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